Peptide Database

Peptide NameNRC-125

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC134H220N36O28

DescriptionStandard

        GLKKWFKKAVHVGKKVGKVALNAYL
    

Molecular Weight2783.40 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)6.84

Net Charge (pH 7.4) 6.57

Charge Density (pH 7.0) 0.2736

GRAVY Index-0.04

Hydrophobic Moment 0.67

Boman Index0.06

Instability Index-20.18

Aliphatic Index 105.20

Aromaticity 0.1200

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1051.65

LogP -4.59

H-bond Donors 37.0

H-bond Acceptors 36.0

Rotatable Bonds 97.0

Heavy Atoms 198.0

Ring Count 5.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0165409 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0191687 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

TargetHuman erythrocytes

Activity>256 μg/mL

MethodHemolysis

RECORD: Rec_0208845 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer

TargetHuman erythrocytes

Activity256 μg/mL

MethodHemolysis

RECORD: Rec_0214448 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 20.0%, E 8.0%, T 44.0%, C 28.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Anticancer Toxic Hemolytic

RECORD: Rec_0290947 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetTumor cells: HL-60 (50% Cell death=16 μg/ml)