Peptide Database

Peptide NameRibonuclease K6 (1-45)[C23,37S]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC243H365N75O65S

DescriptionStandard

        WPKRLTKAHWFEIQHIQPSPLQSNRAMSGINNYTQHSKHQNTFLH
    

Molecular Weight5409.03 Da

Isoelectric Point (pI)10.45

Net Charge (pH 7.0)4.19

Net Charge (pH 7.4) 3.73

Charge Density (pH 7.0) 0.0932

GRAVY Index-1.10

Hydrophobic Moment 0.53

Boman Index-0.14

Instability Index69.04

Aliphatic Index 56.44

Aromaticity 0.1111

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2281.14

LogP -23.62

H-bond Donors 77.0

H-bond Acceptors 75.0

Rotatable Bonds 174.0

Heavy Atoms 384.0

Ring Count 15.0

Amide Bonds 53.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0070756 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0115416 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyBrevinin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetCandida albicans ATCC 90028

RECORD: Rec_0264263 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0414126 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetNot available

RECORD: Rec_0422108 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyBrevinin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetCandida albicans ATCC 90028 (MFC100 = 2.00 ± 0.50 microM (Sabouraud Broth)), C. albicans ATCC 90028 (MFC100 = 1.75 ± 0.30 microM (PBS)), (IC50 = 1.80 ± 0.20 microM)

Activity1.80 ± 0.20 μM

MethodIC50