Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length454 amino acids

Chemical FormulaC2263H3618N602O640S16

DescriptionStandard

        MARALDNTAKWATLMVLATLGTALTVATNPGFVVTISQEGLDYGCQQGIAVLQKKLENINLPNFSGSFKLLGKGYYNFYSLKVLKFQLPSPQLRLQPDVGLQLSTDNNNIIINGKWNAKRGFLKAGGNFVLRVEGISISASLKLGSDPTSGHITVACSSCRDYINRVSLKVSNSKWGWLIRLFQKKIDSLIRKLLDNKICKILSNSVNTNLQRYIRTLPVTSKIDKVADIDYSLVAPPVATADSLTLQMKGEFFRQANRSSPPFDPPVMAIPPGHDRMVYLGMSDYFFNTAGLVFQQAGVLKWTLTNSTVSQMFPSMDVQLVFSTSSPPHLVMEPTGLTFTPNLEVQAFAVLPNSSLASLFLLGMSMNAHLKVSANSDRLVGNLTVDRLLLKLKHSNVGTFPVELLQDAMNYIVPLVAVPKVNERLQKGFPLPVTNGIQLRNLVLRSYQVPESF
    

Molecular Weight50011.62 Da

Isoelectric Point (pI)9.69

Net Charge (pH 7.0)16.91

Net Charge (pH 7.4) 16.29

Charge Density (pH 7.0) 0.0372

GRAVY Index0.07

Hydrophobic Moment 0.80

Boman Index0.11

Instability Index35.57

Aliphatic Index 102.16

Aromaticity 0.0837

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0180837 VERIFIED: NO

Provenance & Taxonomy

OrganismHeterocephalus glaber [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence