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MYP_156694
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Basic Information
LL-37(13-37)
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C137H232N42O36
Standard
Sequence
IGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
3043.57 Da
10.93
3.76
3.55
0.1506
-0.62
0.97
-0.30
36.16
101.20
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1317.13
-10.64
47.0
40.0
107.0
215.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0111223 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli K12
80 μM
MIC
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0136170 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Anticancer
Escherichia coli K12
80 μM
MIC
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0141933 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Anticancer
Drug-resistant KBv cancer cells
39 μM
LC50
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0230743 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli
PaperSolution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
RECORD: Rec_0269687 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa PAO1 / ATCC 15692
5, 10 μM
Crystal violet assay; Total countable CFUs
PaperIdentification of Peptides Derived from the Human Antimicrobial Peptide LL-37 Active against Biofilms Formed by Pseudomonas aeruginosa Using a Library of Truncated Fragments
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