Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2392H3786N638O673S17

DescriptionStandard

        MAREPDKALTRATLVVLATLGTAVIATTNPGVVARITQKGLDYACQQGVAVLQKEMEKITIPTFSGSFKIKHLGKGHYSFHSMAIRGFQLPSSQIKLAPSEGLDLSITNANVKMSGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCSNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTSEICKVVTSSVSSKLQRYLETLPVTTRIDHVAGINYSLVAPPTATTDSLDGQLKGEFFRWAHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGIFIPQVAKMFPNMKVQLVFWASSPPHLTVHPEGLVLAPTLDAQAFAVLPNSSLAPLFVLRLSMNISVTVGATPDRLVGQLSLNRLLLELKHSDIGPFSVEVLQAVMNYVVPIAVIPKVNERLQEGFPLPMPSNVQLFNLVLQSHQNFLLFGADVRYG
    

Molecular Weight52794.62 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)11.70

Net Charge (pH 7.4) 10.62

Charge Density (pH 7.0) 0.0242

GRAVY Index0.12

Hydrophobic Moment 0.71

Boman Index0.14

Instability Index38.11

Aliphatic Index 97.64

Aromaticity 0.0828

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35660.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0270939 VERIFIED: NO

Provenance & Taxonomy

OrganismAcinonyx jubatus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria