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MYP_156679
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Standard
84 amino acids
C342H532N98O118S
Standard
Sequence
GETDPNTQLLNDLGNNMAWGAALGAPGGLGSAALGAAGGALQTVGQGLIDHGPVNVFIPVLIGPSWNGSGSGYNSATSSSGSGS
Physicochemical Analysis
7936.53 Da
4.05
-4.15
-4.41
-0.0494
0.07
0.52
0.28
18.91
81.43
0.0476
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3378.48
-50.44
112.0
116.0
249.0
559.0
12.0
93.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261565 VERIFIED: YES
Provenance & Taxonomy
Klebsiella pneumoniae [Bacterium]
Microcin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli RYC1000, Escherichia coli B, Escherichia coli F., Escherichia coli ML35p, S. enterica Enteritidis, S. enterica Typhimurium, Enterobacter cloacae
PaperIsolation and characterization of microcin E492 from Klebsiella pneumoniae.
RECORD: Rec_0310613 VERIFIED: YES
Provenance & Taxonomy
Klebsiella pneumoniae [Bacterium]
Bacteriocin
573
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Attachment to a siderophore ester
The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a β-D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli C600
0.08 μM
MIC
PMID12890026;15102848;7682973 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12890026/
RECORD: Rec_0313729 VERIFIED: YES
Provenance & Taxonomy
Klebsiella pneumoniae [Bacterium]
Bacteriocin
573
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Attachment to a siderophore ester
The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a β-D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli W3110-KP1344 Pms7
0.08 μM
MIC
PMID12890026;15102848;7682973 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12890026/
RECORD: Rec_0359758 VERIFIED: YES
Provenance & Taxonomy
Klebsiella pneumoniae [Bacterium]
Bacteriocin
573
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Attachment to a siderophore ester
The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a β-D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli W3110-6
0.32 μM
MIC
PMID12890026;15102848;7682973 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12890026/
RECORD: Rec_0388472 VERIFIED: YES
Provenance & Taxonomy
Klebsiella pneumoniae [Bacterium]
Bacteriocin
573
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Attachment to a siderophore ester
The post-translational modification consists of a trimer of N-(2,3-dihydroxybnenzoyl)-L-serine linked via a C-glycosidic linkage to a β-D-glucose moiety, itself linked to the MccE492m Ser-84-carboxyl through an O-glycosidic bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli GM1 KP1060
0.65 μM
MIC
PMID12890026;15102848;7682973 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12890026/
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