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MYP_156629
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Basic Information
Brevinin-1RTb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C120H204N28O28S2
Standard
Sequence
FLGSLLGLVGKVVPTLFCKISKKC
Physicochemical Analysis
2551.20 Da
9.70
3.74
3.50
0.1557
1.08
0.55
0.33
3.46
133.75
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
888.60
-4.58
33.0
34.0
86.0
178.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188147 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 45.8%, C 54.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0216594 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC2592
3.1 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0223961 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
rabbit red blood cells
200 μg/mL
LD50
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0231581 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
RECORD: Rec_0237095 VERIFIED: YES
Provenance & Taxonomy
Amolops ricketti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Psychrobacter faecalis X29
12.5 μg/mL
MIC
PMID22100518 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100518/
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