Peptide Database

Peptide NameSLAY-screened peptide P3908

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H172N32O26S4

DescriptionStandard

        RMSSRILNCTPWRATKMMAI
    

Molecular Weight2366.89 Da

Isoelectric Point (pI)11.71

Net Charge (pH 7.0)3.75

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1875

GRAVY Index-0.09

Hydrophobic Moment 0.61

Boman Index-0.11

Instability Index94.81

Aliphatic Index 68.50

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 958.95

LogP -9.25

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 78.0

Heavy Atoms 162.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0295184 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/