Peptide Database

Peptide NameT-258

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC167H281N47O54

DescriptionStandard

        HRIDLGPPISLERLDVGTNLGNAIAKLEDAKELLE
    

Molecular Weight3811.30 Da

Isoelectric Point (pI)4.83

Net Charge (pH 7.0)-3.13

Net Charge (pH 7.4) -3.40

Charge Density (pH 7.0) -0.0896

GRAVY Index-0.22

Hydrophobic Moment 0.54

Boman Index0.01

Instability Index6.72

Aliphatic Index 128.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1627.40

LogP -14.28

H-bond Donors 54.0

H-bond Acceptors 52.0

Rotatable Bonds 130.0

Heavy Atoms 268.0

Ring Count 3.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0333240 VERIFIED: YES

Provenance & Taxonomy

OrganismMeasles morbillivirus [Virus]

FamilyVirus-derived peptide

Tax ID11234;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Cytoprotective

TargetMeasles virus (Fusion); HEp2

Activity2.2 μM

MethodEC50

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

RECORD: Rec_0365616 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

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