Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC236H376N60O67S4

DescriptionStandard

        MKNTIKDFDLDLKTNKKDIVTPAVGSRYLCTPGSCWKWVCFTTTVK
    

Molecular Weight5254.13 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)3.47

Net Charge (pH 7.4) 3.19

Charge Density (pH 7.0) 0.0754

GRAVY Index-0.27

Hydrophobic Moment 0.46

Boman Index-0.02

Instability Index25.22

Aliphatic Index 69.78

Aromaticity 0.1087

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2068.54

LogP -18.75

H-bond Donors 76.0

H-bond Acceptors 75.0

Rotatable Bonds 172.0

Heavy Atoms 367.0

Ring Count 9.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0168315 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus suis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence