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MYP_156575
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Basic Information
Brevinin-20b
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C152H253N43O42S2
Standard
Sequence
GIFNVFKGALKTAGKHVAGSLLNQLKCKVSGEC
Physicochemical Analysis
3419.03 Da
9.60
3.83
3.53
0.1159
0.22
0.60
0.14
-4.12
94.55
0.0606
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1380.56
-14.47
49.0
49.0
119.0
239.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020711 VERIFIED: NO
Provenance & Taxonomy
Rana ornativentris [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
RECORD: Rec_0084832 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
9 μM
MIC
PaperAntimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris
RECORD: Rec_0109469 VERIFIED: YES
Provenance & Taxonomy
Rana ornativentris [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0160899 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
B. dendrobatidis
6.25 μM
MIC
PaperAntimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris
RECORD: Rec_0190765 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
4 μM
MIC
PaperAntimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris
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