‹ ›
MYP_156565
← PREVIOUS NEXT → BACK
Basic Information
RC-116
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
18 amino acids
C81H142N30O20S6
Standard
Sequence
RYICRCICGRGICRCICG
Physicochemical Analysis
2048.57 Da
8.98
3.70
3.41
0.2055
0.69
0.66
-0.06
-4.18
86.67
0.0556
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
825.85
-8.70
38.0
30.0
67.0
137.0
1.0
17.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0368106 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 5148-1382 | JC53-BL cells
5.2 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0374323 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 92RW009 | JC53-BL cells
7.8 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0387767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 93UG053 | JC53-BL cells
6.6 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0392096 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 93TH060 | JC53-BL cells
6.5 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
FIRST PREV 1 ... 4 5 6
Showing 4 records on this page · Page 6 of 6