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MYP_156565
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Basic Information
RC-116
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
18 amino acids
C81H142N30O20S6
Standard
Sequence
RYICRCICGRGICRCICG
Physicochemical Analysis
2048.57 Da
8.98
3.70
3.41
0.2055
0.69
0.66
-0.06
-4.18
86.67
0.0556
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
825.85
-8.70
38.0
30.0
67.0
137.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002622 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 92UG037 | JC53-BL cells
3.1 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0006775 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 92UG005 | JC53-BL cells
5.2 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0010906 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 193358 | JC53-BL cells
7.8 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0035206 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 196531 | JC53-BL cells
7.8 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
RECORD: Rec_0036899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-17, 6-15, 8-13
Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 HM14 | JC53-BL cells
3.3 μg/mL
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/
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