Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length43 amino acids

Chemical FormulaC187H294N48O68S7

DescriptionStandard

        MEELKNAVMTLTDEELQEAAGAAGCGWACSVTDDCPNSIFVCC
    

Molecular Weight4527.07 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-7.53

Net Charge (pH 7.4) -7.83

Charge Density (pH 7.0) -0.1752

GRAVY Index0.20

Hydrophobic Moment 0.44

Boman Index0.16

Instability Index44.47

Aliphatic Index 70.47

Aromaticity 0.0465

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5750.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1847.36

LogP -21.43

H-bond Donors 66.0

H-bond Acceptors 68.0

Rotatable Bonds 147.0

Heavy Atoms 310.0

Ring Count 4.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0371150 VERIFIED: NO

Provenance & Taxonomy

OrganismBacillus cereus [Bacterium]

FamilyLantibiotic

Tax ID1396

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence