Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length499 amino acids

Chemical FormulaC2378H3744N656O682S18

DescriptionStandard

        MGAGGGRTGRERRAAAGMAARSLAAFGAVLAVCLALTAATNPGFVVRITQAGLDYAHQHGITVLQKELAKLKLPDISGDFPVRRLGKVRYEISSLDLRSFHLPYSRISLVPNVGLQVAISNAFAEVDGNWRVKFHFIRDHGSFNLEVKNVYIKIDLKLGNDASGKPTVSTSACSTRISSVDVHFSGKFGWLYNLFYSAVESRFKKILESKVCDSVVRSVGGDLQHYLQTLPVTAKIDARAGIDYSLVAPPMATAQTLDVDLKGEFFSLAHRGAVPFPPPVLALPPDHDRMVYFGASSYFFNTAGFAYHAAGALVYEITDSMIPKGVEFHLNTSTFAAFIPQLDEMYPNMLMKLRLSAPSAPFLSITPGGISLQPVVDIQAYAILPNTSLAHLFLLSLTGNVSATIDVKSGHIVGKLTVGSRGRCPPAPPSPGSCRQSGPEPSAMSASPPAGHGAPESCGTARVLSPQGQPGAGERGPHAPVALSAQCSSSCVPLQLRCV
    

Molecular Weight53012.32 Da

Isoelectric Point (pI)9.12

Net Charge (pH 7.0)10.75

Net Charge (pH 7.4) 9.56

Charge Density (pH 7.0) 0.0215

GRAVY Index0.09

Hydrophobic Moment 0.70

Boman Index0.13

Instability Index43.09

Aliphatic Index 89.76

Aromaticity 0.0802

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32360.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303867 VERIFIED: NO

Provenance & Taxonomy

OrganismMeleagris gallopavo [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence