Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length480 amino acids

Chemical FormulaC2454H3825N633O703S20

DescriptionStandard

        MMARPHCVVVVLLLLAVVSGLEEGASNPGFVARITRKGLEYARQYGVAILKKELSTIELPDFSGSFKVSWIKIMSYEFYRLKIHDFELRNSDLRLCPRQGVRASLSNNYVSVSGNWKIKKAFFSFDGTFEMKVDDICISAFLNLGKDQSGRLTASMAHCNNSIGHISIDISGKLSWILNLFHERIENKFKNILEQKICEMVEKATTSRLEPYLQTLPVISMIDQVASIDYSLIGAPQVNSQVLDTPFKGEFFGQNGHSRAPFEAPPIRLPEKHDYMVYFAISEYVFNTASWVYHQAGYMNFTIQNQHISPDSPIHLHTSSFPALVPQLARMYPNMELELEMSPESAPLLMFTPGNVTLMPAIDVQAFALKPNSSDRKPLFQLRVTTSISATINVSSDRIVGSVTPGSKLKLELKHSNINFIDVELMEVILNYYALHTIYPSLNAKLEEGFPLPLPVDTYLNSSELQVHENFLLLLANLDY
    

Molecular Weight54084.74 Da

Isoelectric Point (pI)6.17

Net Charge (pH 7.0)-5.27

Net Charge (pH 7.4) -6.39

Charge Density (pH 7.0) -0.0110

GRAVY Index-0.01

Hydrophobic Moment 0.84

Boman Index0.11

Instability Index37.13

Aliphatic Index 97.69

Aromaticity 0.1000

Extinction Coeff. Reduced 48820.00

Extinction Coeff. Oxidized 49070.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415765 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria