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MYP_156343
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Basic Information
65(derived from FIV envelope glycoprotein )
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
20 amino acids
C98H164N32O34S2
Standard
Sequence
MPEVEGEEIQPQMELRRNGR
Physicochemical Analysis
2398.67 Da
4.65
-2.49
-2.71
-0.1243
-1.46
0.53
-0.39
118.50
53.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1100.11
-11.34
36.0
34.0
83.0
166.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009880 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0017234 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Replication inhibition
Feline immunodeficiency virus (FIV) | fibroblastoid cells
16 μg/mL
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 Jun 15;220(2):274-84. | DOI:10.1006/viro.1996.0315 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0230702 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Feline immunodeficiency virus (FIV):inhibition of virus replication in Crandell feline kidney
7 %
Inhibition
PaperPubMed PMID: 8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0376436 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 50.0%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0420153 VERIFIED: YES
Provenance & Taxonomy
Feline immunodeficiency virus [Virus]
Virus-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Feline immunodeficiency virus (Syncytium formation); CrFK
7 %
Syncytia assay
PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/