Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length582 amino acids

Chemical FormulaC2908H4596N782O803S26

DescriptionStandard

        MGCLGRGTNLHTHIHTCTPVYTQACIHAHASLPGCTSPCLWGPNHKGKPQLPSLSPTLARFLPPFRILLTCMSPVDSFIALWSHLKALRSWQLWRMREDVARGLHDAPRWASLLVLVAVGTTVTAAANPGVMVRISQKGLDYASQQGTAALQKELKRIKIPDYSGSFKIKHLGKGRYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKARKSFIKTSGNFDLSVEGVSISADLKLGSDSTSGKPTVSCSSCSSHINSVHVRISNSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPITTAETLDVQMKGEFYSQNHHNPPPFAPAVMEFPAAHDHMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIEIHVSASAPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGVSTTGSMEVGAKSDRLVGKLKVDRLVLELKHSNIGPFPVELLQAVMNYIVPTFVLPRVNEKLQKGFPLPTPARVQLYNMVLQPHQNFLLFGADVVYK
    

Molecular Weight64194.05 Da

Isoelectric Point (pI)9.72

Net Charge (pH 7.0)28.08

Net Charge (pH 7.4) 26.65

Charge Density (pH 7.0) 0.0482

GRAVY Index-0.00

Hydrophobic Moment 0.82

Boman Index0.10

Instability Index42.95

Aliphatic Index 90.93

Aromaticity 0.0876

Extinction Coeff. Reduced 60850.00

Extinction Coeff. Oxidized 61350.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413088 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyBPI

Tax ID9541

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence