Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length124 amino acids

Chemical FormulaC614H974N176O164S6

DescriptionStandard

        PMALPAAREPMLLLAITEFVANSAAFTYFTAGALRRNISSNMLPQRFPLQLRTKSMGHFAPQLQERYPDQPMELHLSARRQPLLSCRPDALHGALFGSAEAFVVLPNATRVPAFLLHLAATARG
    

Molecular Weight13637.77 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.31

Net Charge (pH 7.4) 5.02

Charge Density (pH 7.0) 0.0428

GRAVY Index0.07

Hydrophobic Moment 0.44

Boman Index0.09

Instability Index57.26

Aliphatic Index 91.53

Aromaticity 0.0806

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5349.03

LogP -48.81

H-bond Donors 185.0

H-bond Acceptors 179.0

Rotatable Bonds 432.0

Heavy Atoms 960.0

Ring Count 26.0

Amide Bonds 133.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040808 VERIFIED: NO

Provenance & Taxonomy

OrganismCathartes aura [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria