Peptide Database

Peptide NameVAVY

Function Ontology

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC88H140N28O18

DescriptionStandard

        RRGWVLALVLYYGRR
    

Molecular Weight1878.23 Da

Isoelectric Point (pI)11.55

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.2505

GRAVY Index-0.05

Hydrophobic Moment 0.46

Boman Index-0.12

Instability Index85.18

Aliphatic Index 123.33

Aromaticity 0.2000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 774.57

LogP -3.41

H-bond Donors 31.0

H-bond Acceptors 22.0

Rotatable Bonds 59.0

Heavy Atoms 134.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239969 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial

TargetSheep erythrocytes

Activity0.5 μM

MethodHemolysis

PaperRathinakumar R, Walkenhorst WF, Wimley WC. Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc. 2009 Jun 10;131(22):7609-7617. doi:10.1021/ja8093247. PMID19445503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19445503/

RECORD: Rec_0347321 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial

TargetHuman erythrocytes

Activity5 μM

MethodHemolysis

PaperRathinakumar R, Walkenhorst WF, Wimley WC. Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc. 2009 Jun 10;131(22):7609-7617. doi:10.1021/ja8093247. PMID19445503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19445503/

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