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MYP_156304
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Basic Information
Penaeidin-3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
62 amino acids
C291H456N90O77S6
Standard
Sequence
QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS
Physicochemical Analysis
6639.68 Da
9.89
8.78
8.43
0.1416
-0.38
0.66
-0.04
51.99
51.77
0.0968
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2616.34
-31.11
97.0
93.0
198.0
464.0
17.0
64.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0382196 VERIFIED: YES
Provenance & Taxonomy
Penaeus vannamei [Animal]
PrAMP
6689
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
N-terminus is a pyroglutamic acid. C-terminal amidation. The N-terminus of Pen-3b (I10V) and Pen-3c (P14 deleted) may be Q or pyroglutamic acid. Structure: It contains a Pro-rich domain (PRD) from residue 10 to 28, which is disordered. The cysteine-rich domain (CRD: residues 29-58) displays a folded structure (helix: 41-50; Cys32-Cys47; Cys48-Cys55; Cys36-Cys54). It is proposed that a cooperative interaction between the PRD and CRD domains is important for activity (J Biol Chem 2003; 278: 36859-67)
Bio-Activity Profile
Antimicrobial Antifungal
B. cinerea
5-10 μM
MIC
PaperPenaeidins, a new family of antimicrobial peptides isolated from the shrimp Penaeus vannamei (Decapoda).
RECORD: Rec_0391602 VERIFIED: YES
Provenance & Taxonomy
Arthropoda [Animal]
6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Penicillamine
Bio-Activity Profile
Antimicrobial
PMID11028917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11028917/
RECORD: Rec_0406734 VERIFIED: YES
Provenance & Taxonomy
Penaeus vannamei [Animal]
Penaeidin
6689
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
PaperCell. Mol. Life Sci. 2000; 57: 1260-1271. PubMed. | http://www.ncbi.nlm.nih.gov/pubmed/11028917 PMID11028917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11028917/
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