MYP_156304
Penaeidin-3
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-negative
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
▸
Antifungal
Immunology
▸
Innate immune defense
▸
Host defense peptide
▸
Host defense activity
Standard
62 amino acids
C291H456N90O77S6
Standard
QVYKGGYTRPIPRPPPFVRPLPGGPIGPYNGCPVSCRGISFSQARSCCSRLGRCCHVGKGYS
6639.68 Da
9.89
8.78
8.43
0.1416
-0.38
0.66
-0.04
51.99
51.77
0.0968
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
2616.34
-31.11
97.0
93.0
198.0
464.0
17.0
64.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0353950
VERIFIED: YES
Provenance & Taxonomy
Penaeus vannamei [Animal]
PrAMP
6689
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
N-terminus is a pyroglutamic acid. C-terminal amidation. The N-terminus of Pen-3b (I10V) and Pen-3c (P14 deleted) may be Q or pyroglutamic acid. Structure: It contains a Pro-rich domain (PRD) from residue 10 to 28, which is disordered. The cysteine-rich domain (CRD: residues 29-58) displays a folded structure (helix: 41-50; Cys32-Cys47; Cys48-Cys55; Cys36-Cys54). It is proposed that a cooperative interaction between the PRD and CRD domains is important for activity (J Biol Chem 2003; 278: 36859-67)
Bio-Activity Profile
Antimicrobial
Antifungal
E-carotovora
>40 μM
MIC
RECORD: Rec_0364640
VERIFIED: YES
Provenance & Taxonomy
Litopenaeus vannamei [Animal]
Penaeidin
6689
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
32-47, 36-54, 48-55
O-glycosylated on Thr8
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
Aerococcus viridans
0.3-0.6 μM
MIC
RECORD: Rec_0364932
VERIFIED: YES
Provenance & Taxonomy
Penaeus vannamei [Animal]
PrAMP
6689
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
N-terminus is a pyroglutamic acid. C-terminal amidation. The N-terminus of Pen-3b (I10V) and Pen-3c (P14 deleted) may be Q or pyroglutamic acid. Structure: It contains a Pro-rich domain (PRD) from residue 10 to 28, which is disordered. The cysteine-rich domain (CRD: residues 29-58) displays a folded structure (helix: 41-50; Cys32-Cys47; Cys48-Cys55; Cys36-Cys54). It is proposed that a cooperative interaction between the PRD and CRD domains is important for activity (J Biol Chem 2003; 278: 36859-67)
Bio-Activity Profile
Antimicrobial
Antifungal
yeast C-albicans
>20 μM
MIC
RECORD: Rec_0365543
VERIFIED: YES
Provenance & Taxonomy
Litopenaeus vannamei [Animal]
penaeidin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
32-47; 36-54; 48-55
Bio-Activity Profile
Antimicrobial
penaeidin family
Antibacterial
Antifungal
Host defense
RECORD: Rec_0369951
VERIFIED: YES
Provenance & Taxonomy
Litopenaeus vannamei [Animal]
Penaeidin
6689
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
32-47, 36-54, 48-55
O-glycosylated on Thr8
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
Bacillus megaterium
2.5-5 μM
MIC
Showing 5 records on this page · Page 8 of 9