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MYP_156255
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Basic Information
PGP
Annotation / Sequence feature ▸ Nuclear export signal
Antimicrobial
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibitor
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological regulation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
3 amino acids
C12H19N3O4
Standard
Sequence
PGP
Physicochemical Analysis
269.30 Da
5.96
-0.04
-0.10
-0.0138
-1.20
0.15
0.24
6.67
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
98.74
-1.07
3.0
4.0
4.0
19.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0097793 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
-
RECORD: Rec_0103840 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
0.11 Rcaf
Relative bitterness (Rcaf)
PaperTaste of proline-containing peptides. Agric. Biol. Chem., 52, 95-98, 1988
RECORD: Rec_0189035 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Chemotactic
PaperO'Reilly P. J., Hardison M. T., Jackson P. L., Xu X., Snelgrove R. J., Gaggar A., Galin F. S., Blalock J. E.. Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen. J. Neuroimmunol., 217, 51-54, 2009.
RECORD: Rec_0190565 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiamnestic
PaperAshmarin I. P., Karazeeva E. P., Lyapina L. A., Samonina G. E.. The simplest proline-containing peptides PG, GP, PGP and GPGG: regulatory activity and possible source of biosynthesis. Biochemistry-Moscow, 63, 119-124, 1998.
RECORD: Rec_0206354 VERIFIED: YES
Provenance & Taxonomy
Amaranthus hypochondriacus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anorexic Enzyme inhibitory Test ACE inhibitory
Angiotensin-converting enzyme
66 μM
IC50
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