Peptide Database

Peptide NameSLAY-screened peptide P2046

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC104H164N28O28S3

DescriptionStandard

        RNMMFPDCLGGNPKVSPILFN
    

Molecular Weight2350.78 Da

Isoelectric Point (pI)8.22

Net Charge (pH 7.0)0.75

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0357

GRAVY Index-0.03

Hydrophobic Moment 0.30

Boman Index0.11

Instability Index55.30

Aliphatic Index 69.52

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 893.67

LogP -7.92

H-bond Donors 29.0

H-bond Acceptors 32.0

Rotatable Bonds 73.0

Heavy Atoms 163.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0050610 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/