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MYP_156212
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Basic Information
Cycloviolacin O2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C133H215N37O40S6
Standard
Sequence
GIPCGESCVWIPCISSAIGCSCKSKVCYRN
Physicochemical Analysis
3164.74 Da
8.33
1.70
1.40
0.0567
0.44
0.35
0.16
25.08
74.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1221.14
-14.65
49.0
48.0
99.0
216.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130589 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]; Viola biflora [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Membrane-Binding Hemolytic Anti-barnacle Antiparasitic Anti-Gram-negative
Escherichia coli
80 μM
MIC
PaperPubMed PMID 1247704 | PubMed PMID 8687227 | PubMed PMID 4000000 PMID1247704;8687227;4000000;12477048;68722;74000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1247704/
RECORD: Rec_0130972 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]; Viola biflora [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Membrane-Binding Hemolytic Anti-barnacle Antiparasitic
Human histiocytic lymphoma U-937-Vcr
0.2 μM
IC50
PaperPubMed PMID 1247704 | PubMed PMID 8687227 | PubMed PMID 4000000 PMID1247704;8687227;4000000;12477048;68722;74000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1247704/
RECORD: Rec_0134471 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]; Viola biflora [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Membrane-Binding Hemolytic Anti-barnacle Antiparasitic
Human renal adenocarcinoma ACHN
0.22 μM
IC50
PaperPubMed PMID 1247704 | PubMed PMID 8687227 | PubMed PMID 4000000 PMID1247704;8687227;4000000;12477048;68722;74000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1247704/
RECORD: Rec_0137240 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Also, plant fungi Fusarium oxysporum
6-12.5 μM
MIC
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0141022 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant],Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Insecticidal
CCRF-CEM
0.11 μM
IC50
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 PMID16872274;10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
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