Peptide Database

Peptide NameSLAY-screened peptide P2437

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC93H138N22O25S

DescriptionStandard

        VCVPQAPEYRVFPLYNT
    

Molecular Weight1996.29 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.28

Net Charge (pH 7.4) -0.51

Charge Density (pH 7.0) -0.0162

GRAVY Index0.02

Hydrophobic Moment 0.25

Boman Index0.14

Instability Index45.58

Aliphatic Index 80.00

Aromaticity 0.1765

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 748.62

LogP -4.57

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 55.0

Heavy Atoms 141.0

Ring Count 6.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0170389 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/