Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length458 amino acids

Chemical FormulaC2272H3635N593O637S20

DescriptionStandard

        MFLLKCLPLVALIAAAFSANPGVKIRLTQKGLEYGKQLGMASLLEKLKTAQIPDFSGKERVSPIGKVQYSLTNIHVVNLGLPQSSINLVPGSGVQLSISNAFISLRGNWRVKYLRFIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPRLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIPRSSPIRLSTSTFGFFIPQIAQRFPGLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVVSQRARKEKKLAMSEFPQYYLSAKNLSRALDLMVFRHILFCFTVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
    

Molecular Weight50091.06 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)22.81

Net Charge (pH 7.4) 22.23

Charge Density (pH 7.0) 0.0498

GRAVY Index0.11

Hydrophobic Moment 0.85

Boman Index0.12

Instability Index38.42

Aliphatic Index 97.55

Aromaticity 0.0895

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33600.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0273873 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias latipes [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence