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MYP_155925
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Basic Information
LEAP-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
40 amino acids
C191H320N64O57S5
Standard
Sequence
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
Physicochemical Analysis
4585.30 Da
9.37
3.47
3.19
0.0868
-0.40
0.64
-0.25
75.28
68.25
0.0500
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1989.65
-23.76
78.0
66.0
152.0
317.0
5.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132414 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LEAP-2
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Neisseria cinerea ATCC14685
PMID12493837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12493837/
RECORD: Rec_0140674 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LEAP2 family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
17-28; 23-33
Bio-Activity Profile
Antimicrobial LEAP2 family Antibacterial Host defense
PaperPDB 2L1Q structural record; NMR; chain A; residues 1-40
RECORD: Rec_0177221 VERIFIED: YES
Provenance & Taxonomy
Papio anubis [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0213265 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LEAP-2
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Saccharomyces cerevisiae ATCC9763
PMID12493837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12493837/
RECORD: Rec_0221232 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2148-57
Bio-Activity Profile
Antimicrobial Antifungal
Micrococcus luteus ATCC 9341
100 μM
MIC
PaperIsolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver PMID19852990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19852990/
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