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MYP_155925
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Basic Information
LEAP-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
40 amino acids
C191H320N64O57S5
Standard
Sequence
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE
Physicochemical Analysis
4585.30 Da
9.37
3.47
3.19
0.0868
-0.40
0.64
-0.25
75.28
68.25
0.0500
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1989.65
-23.76
78.0
66.0
152.0
317.0
5.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011251 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LEAP-2
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus megaterium ATCC14581
PMID12493837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12493837/
RECORD: Rec_0024208 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LEAP-2
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC9341
PMID12493837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12493837/
RECORD: Rec_0035909 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 7.5%, E 17.5%, T 45.0%, C 30.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0048747 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Macaca mulatta [Animal]; Mus musculus [Animal]
9606, 10090
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
17-28; 23-33
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0085440 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
LEAP-2
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperLiver-expressed antimicrobial peptide 2 Evidence URLhttps://www.uniprot.org/uniprotkb/Q91V13/entry
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