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MYP_155922
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Basic Information
RJ8-R5G18
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C101H196N60O22
Standard
Sequence
ARRARRRARRAARRARRGARR
Physicochemical Analysis
2603.03 Da
12.00
12.80
12.61
0.6093
-2.20
1.06
-1.34
192.37
33.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1450.02
-20.71
61.0
35.0
93.0
183.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001539 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0035131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
toxicity against Human fibroblasts MRC-5 cells up to 448 μM
448 μM
Cytotoxicity
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0141511 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Infection inhibition
Inhibition of viral infection in MRC-5 cells
4.8 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPrediction of activity, synthesis and biological testing of anti-HSV active peptides. | Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T. | Chem Biol Drug Des. 2006 Jul;68(1):58-66. | DOI:10.1111/j.1747-0285.2006.00412.x | PMID:16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0153663 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus 2(HSV-2):inhibition of viral infection in MRC-5 cells
96 μM
IC50
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0189799 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
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