Peptide Database

Peptide NameSLAY-screened peptide P3994

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H169N35O29

DescriptionStandard

        IRISYRILSHQPSLHPSNSR
    

Molecular Weight2361.66 Da

Isoelectric Point (pI)11.71

Net Charge (pH 7.0)2.93

Net Charge (pH 7.4) 2.63

Charge Density (pH 7.0) 0.1467

GRAVY Index-0.71

Hydrophobic Moment 0.55

Boman Index-0.21

Instability Index47.76

Aliphatic Index 97.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1049.26

LogP -12.38

H-bond Donors 38.0

H-bond Acceptors 34.0

Rotatable Bonds 75.0

Heavy Atoms 167.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0208236 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/