Peptide Database

Peptide NameSLAY-screened peptide P5321

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H181N29O24

DescriptionStandard

        WRRALELGLHLAILYPLPIP
    

Molecular Weight2341.84 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.0425

GRAVY Index0.61

Hydrophobic Moment 0.61

Boman Index0.30

Instability Index62.13

Aliphatic Index 166.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 815.65

LogP 0.20

H-bond Donors 28.0

H-bond Acceptors 26.0

Rotatable Bonds 69.0

Heavy Atoms 167.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288112 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/