Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length533 amino acids

Chemical FormulaC2720H4272N696O746S21

DescriptionStandard

        MGNRSCPPPPAPTAAFLLPLSTSALPFPRRLLYRSQVPIRGLEVWAALEDMTWGPDNVRKWSALVLLAIIGTALTAATDPGFVAMISQKGLDFACQQGVVELQKELQAISVPDFSGVFKIKHLGRGSYEFYSMAVDGFHIPNPEIEMLPSDGLRVFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSNCDSHIDSVHIKISGSMLGWLIRLFHRKIETSLKNIIYKKICKIVRDSVSSKLQPYLKTLSVITRVDDVTSVDYSLVAPLTTTNQFLEGQLKGEFFWRGHRGPLPIHPPVMRFVPNGAYMVCMGISDYFFNTEVFAYQQSGTLKMTLGGQLLSNDGRFQLNTDFLRTFLPKVAKMFPSMGVQLLISAPVPVHLSIQPSGLSFIPKLETQAFVVLPNASLVPLFVLGMKTNASLEVDAEENRLVGEMKLGSRWLLELKESKFGPFKVEYLEDIINYLVPTLVLPKINERLRRGFPLPLPAGIQFSDFTFYPYQNFLLLEADLHLI
    

Molecular Weight59332.60 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)6.36

Net Charge (pH 7.4) 5.43

Charge Density (pH 7.0) 0.0119

GRAVY Index0.13

Hydrophobic Moment 0.86

Boman Index0.15

Instability Index40.43

Aliphatic Index 101.48

Aromaticity 0.0994

Extinction Coeff. Reduced 57870.00

Extinction Coeff. Oxidized 58245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207537 VERIFIED: NO

Provenance & Taxonomy

OrganismMus spicilegus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence