Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2390H3889N659O672S15

DescriptionStandard

        TREDMARGPEGVRSWPALVLLAAVVTAETEATNPGFTTRISQKGLDYACQQGVAVLQKELEKIRIPDVSGKFKLRPFGKGHYNFHSLVVRSFQLPNPQIRLQPNVGLRVSISNANVRIGGRWKARKGFIKVRGKFDLSVEGVSISADLKLGSVPASGRATVTCSSCSSNINRARLRVSGILGWLLKLFHKRIESSLRNTMNSKICQVLTSSVSSKLQPYVETLPLKERLDSVAGIDYSLVAPPRATADSLDMQLKGEFYNVASPSPPPFMPPPMAIPSLHDRMIYLAISDYLFNTAALVYQQAGAFGLTLRDDMIPKESKSRLTTKFLGKALPQVAKMFPNMNVQLTLSVSSPPHLTTRPTGIALTAAVDLQAFAILPNSSLASLFLLGLKLNTSAKIGTKADKLVGELTLGRLILELKHSNIGSFPVELLQALMDYVLSAVVLPKVNEKLQRGLPLPMPRKVQLYDLVLQPHQDFLLLGANVQHG
    

Molecular Weight53088.43 Da

Isoelectric Point (pI)9.96

Net Charge (pH 7.0)24.08

Net Charge (pH 7.4) 23.33

Charge Density (pH 7.0) 0.0495

GRAVY Index0.02

Hydrophobic Moment 0.67

Boman Index0.07

Instability Index42.94

Aliphatic Index 103.52

Aromaticity 0.0638

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096185 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI/LBP

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria