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MYP_155692
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Basic Information
Interferon-induced GTP-binding protein Mx2
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Regulatory peptide ▸ Biological modulation
Standard
655 amino acids
C3276H5281N905O1021S19
Standard
Sequence
MVLSTEENTGVDSVNLPSGETGLGEKDQESVNNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLNEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDRGTEDKVVDVVRNLVYHLKKGYMIVKCRGQQDIQEQLSLTEALQNEQIFFKEHPHFRVLLEDGKATVPCLAERLTAELISHICKSLPLLENQIKESHQSASEELQKYGMDIPEDDSEKTFFLIEKINAFNQDITALVQGEENVAEGECRLFTRLRKEFLSWSKEIEKNFAKGYAVLYNEVWAFEKQYRGRELPGFVNYKTFENIIRRQIKTLEEPAIEMLHTVTEIVRAAFTSVSEKNFSEFYNLHRTTKSKLEDIRLEQEKEAEMSIRLHFKMEQIIYCQDQIYRGALQKVREEEAEEEKKTKHGTSSSSQSQDLQTSSMAEIFQHLNAYRQEAHNRISSHVPLIIQYFILKMFAERLQKGMLQLLQDKDSCSWLLKEQSDTSEKRKFLKERLARLAQARRRLAKFPG
Physicochemical Analysis
74290.66 Da
5.32
-19.37
-20.56
-0.0296
-0.43
1.03
-0.07
48.15
93.91
0.0626
44350.00
44850.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004360 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Mx
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor Anti-HNTV
Hantavirus(HNTV)
PaperMouse Mx2 protein inhibits hantavirus but not influenza virus replication. PMID11266216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11266216/
RECORD: Rec_0283624 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Mx
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Interferon pathway modulator Anti-VSV Anti-HNTV
Vesicular stomatitis virus(VSV)/Hantaan virus(HNTV)
PaperHuman MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. PMID21166595 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21166595/
RECORD: Rec_0420306 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Mx
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor Interferon pathway modulator Anti-VSV
Vesicular stomatitis virus(VSV)
PaperIdentification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. PMID10233954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10233954/