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MYP_155655
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Basic Information
D Tachyplesin [C3,7,12,16Del]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C87H134N30O16
Standard
Sequence
KWFRVYRGIYRRR
Physicochemical Analysis
1856.19 Da
11.84
5.76
5.55
0.4429
-1.45
0.87
-0.67
52.48
52.31
0.3077
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
804.29
-4.14
33.0
22.0
60.0
133.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0277728 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0309145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
37180 μM
IC50
PMID16700563;28641565 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16700563/
RECORD: Rec_0311864 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 11774
200 μg/mL
MIC
PMID16700563;28641565 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16700563/
RECORD: Rec_0354615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli C25 IC90
9.7 μM
PMID16700563;28641565 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16700563/
RECORD: Rec_0385865 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tachyplesin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
k=D-Lys; w=D-Trp; f=D-Phe; r=D-Arg; v=D-Val; y=D-Tyr; i=D-Ile
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Sheep erythrocytes
<1 %
Hemolysis
PaperPubMed PMID: 28641565 PMID28641565 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28641565/
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