Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length186 amino acids

Chemical FormulaC934H1477N251O254S9

DescriptionStandard

        PMAPPMTHEPMLLLAVTEFVANSAAFTYFTAGALHRTISSDMLPRRFPLQLRTKSMEVFSPQLQERYPDQPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELPQGLPVLQVKRLETVLKFGLWLFGIPQANSKCCPSPVP
    

Molecular Weight20574.83 Da

Isoelectric Point (pI)9.01

Net Charge (pH 7.0)3.39

Net Charge (pH 7.4) 3.00

Charge Density (pH 7.0) 0.0182

GRAVY Index0.03

Hydrophobic Moment 0.57

Boman Index0.11

Instability Index55.41

Aliphatic Index 93.33

Aromaticity 0.0753

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7891.45

LogP -90.18

H-bond Donors 268.0

H-bond Acceptors 271.0

Rotatable Bonds 645.0

Heavy Atoms 1448.0

Ring Count 43.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001014 VERIFIED: NO

Provenance & Taxonomy

OrganismToxostoma redivivum [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria