Peptide Database

Peptide NameSLAY-screened peptide P2178

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H156N28O27S

DescriptionStandard

        TAVCFRARFPQVSYALNTLG
    

Molecular Weight2214.54 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)1.39

Net Charge (pH 7.4) 1.18

Charge Density (pH 7.0) 0.0694

GRAVY Index0.40

Hydrophobic Moment 0.40

Boman Index0.14

Instability Index32.59

Aliphatic Index 83.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 898.33

LogP -9.00

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 67.0

Heavy Atoms 156.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0100830 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/