Peptide Database

Peptide NameSLAY-screened peptide P954

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H158N32O30S

DescriptionStandard

        TCRPFSAAYLFDDRHNIRPT
    

Molecular Weight2380.64 Da

Isoelectric Point (pI)7.92

Net Charge (pH 7.0)0.48

Net Charge (pH 7.4) 0.22

Charge Density (pH 7.0) 0.0238

GRAVY Index-0.69

Hydrophobic Moment 0.26

Boman Index-0.20

Instability Index84.23

Aliphatic Index 49.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1011.63

LogP -10.55

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 71.0

Heavy Atoms 168.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0189577 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/