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MYP_155514
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Basic Information
Buforin II
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Anti-endotoxin
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C106H184N40O26
Standard
Sequence
TRSSRAGLQFPVGRVHRLLRK
Physicochemical Analysis
2434.85 Da
12.00
5.48
5.24
0.2612
-0.64
0.81
-0.36
84.20
88.10
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1104.51
-12.38
42.0
33.0
82.0
172.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0204167 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
① The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis
2 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0206787 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Bufo Bufo Gargarizans
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
U-937
0.5 μg/mL
Cytotoxicity assay
PMID8573171;21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0224453 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli BL21
0.33±0.005 μM
ED50
PMID30044391 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30044391/
RECORD: Rec_0232076 VERIFIED: NO
Provenance & Taxonomy
Bufo gargarizans [Animal]
Buforin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37276
RECORD: Rec_0232899 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
① The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
4 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
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