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MYP_155514
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Basic Information
Buforin II
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Anti-endotoxin
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C106H184N40O26
Standard
Sequence
TRSSRAGLQFPVGRVHRLLRK
Physicochemical Analysis
2434.85 Da
12.00
5.48
5.24
0.2612
-0.64
0.81
-0.36
84.20
88.10
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1104.51
-12.38
42.0
33.0
82.0
172.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0171502 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0171563 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
① The residue at position 21 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
4 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0194866 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa M18C1
100 μM
ED50
PMID30044391 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30044391/
RECORD: Rec_0197339 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 502A
0.51±0.02 μM
ED50
PMID30044391 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30044391/
RECORD: Rec_0202162 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Buforin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
>41.1 μM
IC50
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
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