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MYP_155514
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Basic Information
Buforin II
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Anti-endotoxin
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C106H184N40O26
Standard
Sequence
TRSSRAGLQFPVGRVHRLLRK
Physicochemical Analysis
2434.85 Da
12.00
5.48
5.24
0.2612
-0.64
0.81
-0.36
84.20
88.10
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1104.51
-12.38
42.0
33.0
82.0
172.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037086 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
4 μg/mL
MIC
PMID8573171 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0050951 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Buforin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Not included yet
Not included yet
Bio-Activity Profile
Antimicrobial Anticancer
U-937
PaperAntitumor activity of antimicrobial peptides against U937 histiocytic cell line PMID21403917 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21403917/
RECORD: Rec_0055335 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Cryptococcus neoformans
1 μg/mL
MIC
PMID8573171 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0059083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Buforin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
P. putida
2 μg/mL
MIC
PaperA novel antimicrobial peptide from Bufo bufo gargarizans.
RECORD: Rec_0068980 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
2 μg/mL
MIC
PMID8573171 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
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