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MYP_155514
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Basic Information
Buforin II
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Binding / Molecular interaction ▸ Binding activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Anti-endotoxin
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C106H184N40O26
Standard
Sequence
TRSSRAGLQFPVGRVHRLLRK
Physicochemical Analysis
2434.85 Da
12.00
5.48
5.24
0.2612
-0.64
0.81
-0.36
84.20
88.10
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1104.51
-12.38
42.0
33.0
82.0
172.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0326893 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0331796 VERIFIED: YES
Provenance & Taxonomy
Sphaenorhynchus lacteus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 39413
6.46±0.002 μM
ED50
PMID30044391 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30044391/
RECORD: Rec_0344052 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Buforin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
1.6 μM
MIC
PaperC.B. Park et al. / Proc. Natl. Acad. Sci. USA 97 (2000) 8245-8250. Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II
RECORD: Rec_0350695 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Buforin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Escherichia coli
4 μg/mL
MIC
PaperA novel antimicrobial peptide from Bufo bufo gargarizans.
RECORD: Rec_0355575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Buforin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
S. pneumoniae
4 μg/mL
MIC
PaperA novel antimicrobial peptide from Bufo bufo gargarizans.
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