Peptide Database

Peptide NameSLAY-screened peptide P3950

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H149N23O32S3

DescriptionStandard

        GCDSYSTILLNCINPCYNYL
    

Molecular Weight2269.57 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.27

Net Charge (pH 7.4) -1.52

Charge Density (pH 7.0) -0.0636

GRAVY Index0.28

Hydrophobic Moment 0.43

Boman Index0.23

Instability Index31.74

Aliphatic Index 97.50

Aromaticity 0.1500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 895.38

LogP -8.92

H-bond Donors 33.0

H-bond Acceptors 34.0

Rotatable Bonds 68.0

Heavy Atoms 157.0

Ring Count 4.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0371466 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/