Peptide Database

Peptide Name1OAN1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H182N34O26S

DescriptionStandard

        FWFTLIKTQAKQPARYRRFC
    

Molecular Weight2561.02 Da

Isoelectric Point (pI)11.01

Net Charge (pH 7.0)4.75

Net Charge (pH 7.4) 4.53

Charge Density (pH 7.0) 0.2374

GRAVY Index-0.54

Hydrophobic Moment 0.56

Boman Index-0.18

Instability Index48.98

Aliphatic Index 49.00

Aromaticity 0.2500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1007.83

LogP -6.08

H-bond Donors 38.0

H-bond Acceptors 32.0

Rotatable Bonds 81.0

Heavy Atoms 182.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0394051 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetDengue 2 virus (Virus entry); LLC-MK2

Activity7 μM

MethodFocus reduction assay

PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/

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