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MYP_155487
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Basic Information
1OAN1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C121H182N34O26S
Standard
Sequence
FWFTLIKTQAKQPARYRRFC
Physicochemical Analysis
2561.02 Da
11.01
4.75
4.53
0.2374
-0.54
0.56
-0.18
48.98
49.00
0.2500
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1007.83
-6.08
38.0
32.0
81.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0176849 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Antibody dependent enhancement effect); K562
3 μM
ADE inhibition assay
PaperViral entry inhibitors block dengue antibody-dependent enhancement in vitro. | Nicholson CO, Costin JM, Rowe DK, Lin L, Jenwitheesuk E, Samudrala R, Isern S, Michael SF. | Antiviral Res. 2011 | PMID:21093488 PMID21093488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21093488/
RECORD: Rec_0248993 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0263336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
90-100 % Inhibition
Inhibition
PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0336187 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue 2 virus(DENV-2) | LLC-MK2 cells
7±4 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721. | DOI:10.1371/journal.pntd.0000721 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0352610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
dengue 2 virus(DENV-2):inhibition of virus infection in LLC-MK2 cells
7±4 μM
IC50
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
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