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MYP_155487
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Basic Information
1OAN1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
20 amino acids
C121H182N34O26S
Standard
Sequence
FWFTLIKTQAKQPARYRRFC
Physicochemical Analysis
2561.02 Da
11.01
4.75
4.53
0.2374
-0.54
0.56
-0.18
48.98
49.00
0.2500
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1007.83
-6.08
38.0
32.0
81.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0047831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
LLC-MK2 cells
50 μM
Cytotoxicity assay (no toxicity observed)
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0085736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
LLC-MK2 cells
Cytotoxicity assay
PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0105981 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 15.0%, E 0.0%, T 35.0%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0160396 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0176849 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Antibody dependent enhancement effect); K562
3 μM
ADE inhibition assay
PaperViral entry inhibitors block dengue antibody-dependent enhancement in vitro. | Nicholson CO, Costin JM, Rowe DK, Lin L, Jenwitheesuk E, Samudrala R, Isern S, Michael SF. | Antiviral Res. 2011 | PMID:21093488 PMID21093488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21093488/
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