Peptide Database

Peptide NameBasic phospholipase A2 BbTX-III (svPLA2) (EC 3.1.1.4) (Brazilitoxin III) (BbTX-III) (Phosphatidylcholine 2-acylhydrolase)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme modulation ▸ Enzyme inhibition ▸ Blood coagulation cascade inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length121 amino acids

Chemical FormulaC618H948N174O176S16

DescriptionStandard

        SLWEWGQMILKETGKNPFPYYGAYGCYCGWGGRRKPKDATDRCCFVHDCCRYKKLTGCPKTNDRYSYSRLDYTIVCGEDDPCKEICECDKAAAVCFRENLRTYNKKYMAHLRVLCKKDKPC
    

Molecular Weight14144.24 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)7.50

Net Charge (pH 7.4) 6.93

Charge Density (pH 7.0) 0.0620

GRAVY Index-0.76

Hydrophobic Moment 0.66

Boman Index-0.19

Instability Index26.66

Aliphatic Index 46.78

Aromaticity 0.1322

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 32275.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5688.01

LogP -53.00

H-bond Donors 215.0

H-bond Acceptors 202.0

Rotatable Bonds 463.0

Heavy Atoms 984.0

Ring Count 27.0

Amide Bonds 125.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0170130 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0205189 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetLeishmania

RECORD: Rec_0295735 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops brazili [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetCandida albicans