Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length498 amino acids

Chemical FormulaC2455H3868N630O715S17

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYGSHIGADWMQEKIGSVIIPDVRGGVDIGIGTVHYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISMSGNWHTRFGIITDGGSFDLAVFNVDVTSVVQIGSDPSGHISISSKNCDAKVGEASINFHGGASLIFQPFVSLFHHRIKAIIEERICPLVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFHLAEDKGHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKTSPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDLPMFSFQADKLTMEFPGAVKAFAIQPNASRTPLFKLNVDSIFSGTIRISEEKLKGLVELSNFTLTLASSEVGTFQTAALEKFMKLGMKISVLAKLNAKLEEGIVLPTMHHIHLVNPALKIQQGFVSIASDLDVKSGEGESLSEGIYHYRLVRYGKVYKATVNM
    

Molecular Weight54193.87 Da

Isoelectric Point (pI)5.86

Net Charge (pH 7.0)-9.98

Net Charge (pH 7.4) -11.22

Charge Density (pH 7.0) -0.0200

GRAVY Index0.17

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index30.07

Aliphatic Index 102.75

Aromaticity 0.0823

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27515.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0046249 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus kisutch [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence