Peptide Database

Peptide NameSLAY-screened peptide P4684

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H150N26O35S

DescriptionStandard

        SLFDDTPRYTWSSANNYLYC
    

Molecular Weight2416.58 Da

Isoelectric Point (pI)4.21

Net Charge (pH 7.0)-1.55

Net Charge (pH 7.4) -1.78

Charge Density (pH 7.0) -0.0775

GRAVY Index-0.70

Hydrophobic Moment 0.44

Boman Index-0.03

Instability Index-1.51

Aliphatic Index 44.00

Aromaticity 0.2500

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1007.74

LogP -10.33

H-bond Donors 37.0

H-bond Acceptors 35.0

Rotatable Bonds 70.0

Heavy Atoms 171.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108359 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/